http://www.sec.gov/Archives/edgar/data/821533/000104746918004357/a2235953z424b5.htm
http://www.sec.gov/Archives/edgar/data/1593538/000119312518188198/d589323d424b2.htm
http://www.sec.gov/Archives/edgar/data/1494650/000162828018007719/optinose424b4.htm